AJLM African Journal of Laboratory Medicine 2225-2002 2225-2010 AOSIS AJLM-10-1471 10.4102/ajlm.v10i1.1471 Scientific Letter Post-mortem diagnosis of COVID-19 https://orcid.org/0000-0003-0078-7897 Mungmungpuntipantip Rujittika 1 https://orcid.org/0000-0003-1039-3728 Wiwanitkit Viroj 2 Private Practice, Bangkok, Thailand Department of Community Medicine, DY Patil University, Pune, India Corresponding author: Rujittika Mungmungpuntipantip, rujittika@gmail.com 24032021 2021 10 1 1471 26112020 23122020 © 2021. The Authors 2021 Licensee: AOSIS. This work is licensed under the Creative Commons Attribution License.

We would like to share our impression on the report ‘Postmortem diagnosis of COVID-19: Antemortem challenges of three cases at the 37 Military Hospital, Accra, Ghana’.1 Attoh et al. concluded that ‘The outcome of COVID-19 testing is dependent on the sample type and accuracy of sampling amongst other factors’1 and suggested that ‘more autopsies are required to fully understand the pathogenesis of this disease in Ghanaians’.1 Indeed, post-mortem diagnosis of coronavirus disease 2019 (COVID-19) is possible and there are many reports of the existence of pathogenic viruses in autopsy specimens.2,3 Autopsy is also very useful for understanding the pathogenesis of this new disease. However, it must be performed with high caution. While there are no confirmed cases of the pathogen being spread from deceased patients, infection of forensic pathology workers has been reported.4 More autopsies might be recommended, but adequate biosafety and biosecurity, and other infection control precautions must be in place for these to occur.

 Response from Attoh et al.

In our article we did not go into details on the methodology. Although COVID-19 is a category 3 infectious agent, negative pressure systems are unavailable in our country. Therefore, a few modifications were made.

Post-mortems were performed using World Health Organization’s interim guidance for infection prevention and control for the safe management of a dead body in the context of COVID-19.5 The structural design of the autopsy suites used lacked negative pressure systems with filters. As a result, extractors were fitted to provide unidirectional airflow away from the anatomical pathology team into the atmosphere as an appropriate technology. Also, members of the anatomical pathology team were carefully selected to exclude those with chronic health conditions such as diabetes mellitus, and cardiovascular and respiratory diseases.

It is interesting to note that none of the forensic pathologists nor the anatomical pathology technicians involved in the study have shown COVID-19 symptoms up to today.

 Acknowledgements Competing interests

The authors have declared that no competing interests exist.

 Authors’ contributions

R.M. and V.W. have equal contributions in giving ideas, drafting, analysing, writing and giving final approval for this submission.

 Ethical considerations

This article followed all ethical standards for research without direct contact with human or animal subjects.

 Sources of support

This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

 Data availability statement

Data sharing is not applicable to this article as no new data were created or analysed in this study.

 Disclaimer

The views and opinions expressed in this article are those of the authors and do not necessarily reflect the official policy or position of any affiliated agency of the authors.

 References Attoh SA, Hobenu F, Edusei L, et al. Postmortem diagnosis of COVID-19: Antemortem challenges of three cases at the 37 Military Hospital, Accra, Ghana. Afr J Lab Med. 2020 Nov 3;9(1):a1290. https://doi.org/10.4102/ajlm.v9i1.1290 Sawant OB, Singh S, Wright 3rd, RE, et al. Prevalence of SARS-CoV-2 in human post-mortem ocular tissues. Ocul Surf. 2020;Nov 8;S1542-0124(20)30168–3. Zijlstra JG, Van Meurs M, Moser J. Post-mortem diagnostics in COVID-19 AKI, more often but timely. J Am Soc Nephrol. 2021;32(1):255. https://doi.org/10.1681/ASN.2020091263 Sriwijitalai W, Wiwanitkit V. COVID-19 in forensic medicine unit personnel: Observation from Thailand. J Forensic Leg Med. 2020 May;72:101964. https://doi.org/10.1016/j.jflm.2020.101964 World Health Organization (WHO). Infection prevention and control for the safe management of a dead body in the context of COVID-19: Interim guidance [homepage on the Internet]. World Health Organization, 2020; p. 6. WHO reference number: WHO/2019-nCoV/IPC_DBMgmt/2020.2. Available from: https://www.who.int/publications/i/item/infection-prevention-and-control-for-the-safe-management-of-a-dead-body-in-the-context-of-covid-19-interim-guidance

How to cite this article: Mungmungpuntipantip R, Wiwanitkit V. Post-mortem diagnosis of COVID-19. Afr J Lab Med. 2021;10(1), a1471. https://doi.org/10.4102/ajlm.v10i1.1471