Original Research

Sensitivity and specificity of mean platelet volume as a laboratory marker for irritable bowel syndrome: Can it be added to Rome criteria?

Mostafa Vaghari-Tabari, Soheila Moein, Durdi Qujeq, Mehrdad Kashifard, Haydeh Alaoddolehei, Karimollah Hajian-Tilaki
African Journal of Laboratory Medicine | Vol 9, No 1 | a1001 | DOI: https://doi.org/10.4102/ajlm.v9i1.1001 | © 2020 Mostafa Vaghari-Tabari, Soheila Moein, Durdi Qujeq, Mehrdad Kashifard, Haydeh Alaoddolehei, Karimollah Hajian-Tilaki | This work is licensed under CC Attribution 4.0
Submitted: 24 February 2019 | Published: 21 December 2020

About the author(s)

Mostafa Vaghari-Tabari, Department of Clinical Biochemistry and Laboratory Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; and, Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Soheila Moein, Molecular Medicine Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran; and, Department of Biochemistry, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
Durdi Qujeq, (CMBRC), Health Research Insititute, Babol University of Medical Sciences, Babol, Iran; and, Department of Clinical Biochemistry, Babol University of Medical Sciences, Babol, Iran
Mehrdad Kashifard, Department of Internal Medicine, Gastroenterology Division, Ayatollah Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran
Haydeh Alaoddolehei, Department of Hematology and Medical Laboratory Sciences, Para Medical Faculty, Babol University of Medical Sciences, Babol, Iran
Karimollah Hajian-Tilaki, Department of Biostatistics and Epidemiology, Babol University of Medical Sciences, Babol, Iran


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Abstract

Background: Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder.

Objective: This study aimed to evaluate red blood cell distribution width (RDW) and mean platelet volume (MPV) as laboratory markers to discriminate IBS patients from both healthy controls and patients with inflammatory bowel disease (IBD).

Methods: This case-control study enrolled patients referred to Ayatollah Rouhani Hospital, Endoscopy Department, Babol, Iran, for colonoscopy examination from 2015 to 2017. Fifty IBS patients were selected from among patients who had undergone a normal colonoscopy and showed symptoms matching the Rome III criteria. Fifty healthy participants and 50 IBD patients, matched for sex and age, were also enrolled in this study. Both RDW and MPV were measured and analysed by independent sample t-test and receiver operating characteristic curve analysis. A p-value of less than 0.05 was considered statistically significant.

Results: While RDW was higher and MPV was lower among IBS patients compared to healthy controls (p = 0.047 and p = 0.001), there were no significant differences in RDW or MPV levels between IBS and IBD patients. The area under the curve of RDW in the discrimination between IBS and IBD was 0.620 (p = 0.039), and the area under the curve of MPV in the discrimination between healthy controls and IBS patients was 0.801 (p = 0.001).

Conclusion: Mean platelet volume is potentially a useful laboratory marker for distinguishing between IBS patients and healthy individuals. Red blood cell distribution width should be considered as a potential marker to distinguish among IBS and IBD patients.


Keywords

IBS; irritable bowel syndrome; inflammatory bowel disease; red blood cell distribution width; mean platelet volume

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