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Original Research
Field evaluation of a mobile biosafety laboratory in Senegal to strengthen rapid disease outbreak response and monitoring
Submitted: 25 April 2019 | Published: 20 August 2020
About the author(s)
Cheikh Fall, Department of Virology, Institut Pasteur de Dakar, Dakar, SenegalAurélie Cappuyns, Praesens Foundation, Brussels, Belgium
Oumar Faye, Department of Virology, Institut Pasteur de Dakar, Dakar, Senegal
Steven Pauwels, Praesens Foundation, Brussels, Belgium
Gamou Fall, Department of Virology, Institut Pasteur de Dakar, Dakar, Senegal
Ndongo Dia, Department of Virology, Institut Pasteur de Dakar, Dakar, Senegal
Moussa M. Diagne, Department of Virology, Institut Pasteur de Dakar, Dakar, Senegal
Cheikh T. Diagne, Department of Virology, Institut Pasteur de Dakar, Dakar, Senegal
Makhtar Niang, Department of Virology, Institut Pasteur de Dakar, Dakar, Senegal
Alassane Mbengue, Department of Virology, Institut Pasteur de Dakar, Dakar, Senegal
Martin Faye, Department of Virology, Institut Pasteur de Dakar, Dakar, Senegal
Idrissa Dieng, Department of Virology, Institut Pasteur de Dakar, Dakar, Senegal
Babacar Gningue, Quality Department, Institut Pasteur de Dakar, Dakar, Senegal
Abdoulaye Bousso, Senegalese Health Emergency Operation Center, Ministry of Health, Dakar, Senegal
Ousmane Faye, Department of Virology, Institut Pasteur de Dakar, Dakar, Senegal
Rudi Pauwels, Praesens Foundation, Brussels, Belgium
Amadou A. Sall, Department of Virology, Institut Pasteur de Dakar, Dakar, Senegal
Abstract
Background: Past and recent outbreaks have highlighted the vulnerability of humans to infectious diseases, which represent serious economic and health security threats. A paradigm shift in the management of sanitary crises is urgently needed. Based on lessons from the 2014 Ebola outbreak, the Praesens Foundation has developed an all-terrain mobile biosafety laboratory (MBS-Lab) for effective field diagnostics capabilities.
Objective: The aim of the study was to train African teams and run a field evaluation of the MBS-Lab, including robustness, technical and operational sustainability, biosafety, connectivity, turn-around times for testing and result delivery.
Methods: The MBS-Lab was deployed in Senegal in October 2017 for a six-month field assessment under various ecological conditions and was mobilised during the dengue outbreaks in 2017 and 2018.
Results: The MBS-Lab can be considered an off-grid solution that addresses field challenges with regard to working conditions, mobility, deployment, environment and personnel safety. Blood (n = 398) and nasal swab (n = 113) samples were collected from 460 study participants for molecular screening for acute febrile illnesses and respiratory infections. The results showed that malaria (particularly in Kédougou) and upper respiratory tract infections remain problematic. Suspected dengue samples were tested on board during the dengue outbreaks in 2017 (882 tests; 128 confirmed cases) and 2018 (1736 tests; 202 confirmed cases).
Conclusion: The MBS-Lab is an innovative solution for outbreak response, even in remote areas. The study demonstrated successful local ownership and community engagement. The MBS-Lab can also be considered an open mobile healthcare platform that offers various opportunities for field-deployable, point-of-care technologies for surveillance programmes.
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Crossref Citations
1. Screening High-Risk Groups and the General Population for SARS-CoV-2 Nucleic Acids in a Mobile Biosafety Laboratory
Zhimin Guo, Lin Li, Yuanyuan Song, Jiancheng Xu, Jing Huang
Frontiers in Public Health vol: 9 year: 2021
doi: 10.3389/fpubh.2021.708476