Review Article

Beta-lactamase resistance genes in Enterobacteriaceae from Nigeria

Babafela B. Awosile, Michael Agbaje, Oluwawemimo Adebowale, Olugbenga Kehinde, Ezekiel Omoshaba
African Journal of Laboratory Medicine | Vol 11, No 1 | a1371 | DOI: https://doi.org/10.4102/ajlm.v11i1.1371 | © 2022 Babafela Babalola Awosile, Michael Agbaje, Oluwawemimo Adebowale, Olugbenga Kehinde, Ezekiel Omoshaba | This work is licensed under CC Attribution 4.0
Submitted: 26 August 2020 | Published: 22 February 2022

About the author(s)

Babafela B. Awosile, Texas Tech University School of Veterinary Medicine, Amarillo, Texas, United States
Michael Agbaje, Department of Veterinary Microbiology, College of Veterinary Medicine, Federal University of Agriculture, Abeokuta, Nigeria
Oluwawemimo Adebowale, Department of Veterinary Public Health and Preventive Medicine, College of Veterinary Medicine, Federal University of Agriculture, Abeokuta, Nigeria
Olugbenga Kehinde, Department of Veterinary Public Health and Preventive Medicine, College of Veterinary Medicine, Federal University of Agriculture, Abeokuta, Nigeria
Ezekiel Omoshaba, Department of Veterinary Microbiology, College of Veterinary Medicine, Federal University of Agriculture, Abeokuta, Nigeria


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Abstract

Background: Beta-lactamase genes are one of the most important groups of antimicrobial resistance genes in human and animal health. Therefore, continuous surveillance of this group of resistance genes is needed for a better understanding of the local epidemiology within a country and global dissemination.

Aim: This review was carried out to identify different beta-lactamase resistance genes reported in published literature from Nigeria.

Methods: Systematic review and meta-analysis was carried out on eligible Nigerian articles retrieved from electronic literature searches of PubMed®, African Journals Online, and Google Scholar published between January 1990 and December 2019. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses method was adopted to facilitate clarity and transparency in reporting review findings.

Results: Fifty-seven articles were included. All beta-lactamases reported were detected from Gram-negative bacteria, particularly from Enterobacteriaceae. Thirty-six different beta-lactamase genes were reported in Nigeria. These genes belong to the narrow-spectrum, AmpC, extended-spectrum and carbapenemase beta-lactamase resistance genes. The pooled proportion estimate of extended-spectrum beta-lactamase genes in Nigeria was 31% (95% confidence interval [CI]: 26% – 36%, p < 0.0001), while the estimate of the blaCTX-M-15 gene in Nigeria was 46% (95% CI: 36% – 57%, p < 0.0001). The proportion estimate of AmpC genes was 32% (95% CI: 11% – 52%, p < 0.001), while the estimate for carbapenemases was 8% (95% CI: 5% – 12%, p < 0.001).

Conclusion: This study provides information on beta-lactamase distribution in Nigeria. This is necessary for a better understanding of molecular epidemiology of clinically important beta-lactamases, especially the extended-spectrum beta-lactamases and carbapenemases in Nigeria.

 


Keywords

antimicrobial resistance; beta-lactamase gene; Nigeria; review; epidemiology

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