Case Study

Prolonged febrile illness due to CTX-M-15 extendedspectrum β-lactamase-producing Klebsiella pneumoniae infection in Nigeria

Oladipo A. Aboderin, Olufemi Adefehinti, Babatunde W. Odetoyin, Amadin A. Olotu, Iruka N. Okeke, Olugbenga Adeodu
African Journal of Laboratory Medicine | Vol 1, No 1 | a16 | DOI: https://doi.org/10.4102/ajlm.v1i1.16 | © 2012 Oladipo A. Aboderin, Olufemi Adefehinti, Babatunde W. Odetoyin, Amadin A. Olotu, Iruka N. Okeke, Olugbenga Adeodu | This work is licensed under CC Attribution 4.0
Submitted: 09 December 2011 | Published: 04 June 2012

About the author(s)

Oladipo A. Aboderin, Department of Medical Microbiology and Parasitology, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria Department of Medical Microbiology and Parasitology, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria, Nigeria
Olufemi Adefehinti, Department of Paediatrics, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria, Nigeria
Babatunde W. Odetoyin, Department of Medical Microbiology and Parasitology, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria
Amadin A. Olotu, Department of Medical Microbiology and Parasitology, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria
Iruka N. Okeke, Department of Biology, Haverford College, Haverford, PA, Nigeria
Olugbenga Adeodu, Department of Medical Microbiology and Parasitology, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife Department of Paediatrics and Child Health, Obafemi Awolowo University, Ile-Ife, Nigeria


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Abstract

We report on an 8-year-old patient with septicaemia unresponsive to therapy for five weeks. Undetected, extended-spectrum β-lactamase (ESBL) production by the infecting Klebsiella strain was regarded as responsible for treatment failure. Intravenously administered imipenem during the sixth week led to sustained resolution of fever. Resource-limited hospitals can incur prohibitive costs from ESBL-producer infections because of diagnostic limitations and consequent treatment failure involving prolonged supportive therapy.

Keywords

septicaemia; CTX-M-15; Klebsiella pneumoniae; Nigeria

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