Email this article 
Hide
Show all
Original Research
HIV and Tuberculosis co-infection impacts T-cell activation markers but not the numbers subset of regulatory T-cells in HIV-1 infected patients
Submitted: 30 June 2012 | Published: 02 September 2013
About the author(s)
Moustapha Mbow, Laborarotory of Bacteriology and Virology Aristide Le Dantec teaching hospital, Immunology Unit, Dakar, Senegal, SenegalNdèye S.S. Santos, Laboratory of Bacteriology and Virology, Aristide Le Dantec University Hospital, Dakar, Senegal
Makhtar Camara, Laboratory of Bacteriology and Virology, Aristide Le Dantec University Hospital, Dakar, Senegal
Awa Ba, Laboratory of Bacteriology and Virology, Aristide Le Dantec University Hospital, Dakar, Senegal
Aliou Niang, Department of Pneumophthisiology, Fann University Hospital, Dakar, Senegal
Géraldine Daneau, Institute of Tropical Medicine, Unit of Immunology, Department of Biomedical Sciences, Antwerp, Belgium
Djibril Wade, Institute of Tropical Medicine, Unit of Immunology, Department of Biomedical Sciences, Antwerp, Belgium
Abdou A. Diallo, Laboratory of Bacteriology and Virology, Aristide Le Dantec University Hospital, Dakar, Senegal
Maxim Toupane, Laboratory of Bacteriology and Virology, Aristide Le Dantec University Hospital, Dakar, Senegal
Maïmouna Diakhaté, Laboratory of Bacteriology and Virology, Aristide Le Dantec University Hospital, Dakar, Senegal
Nafissatou Lèye, Laboratory of Bacteriology and Virology, Aristide Le Dantec University Hospital, Dakar, Senegal
Papa A. Diaw, Laboratory of Bacteriology and Virology, Aristide Le Dantec University Hospital, Dakar, Senegal
Souleymane Mboup, Laboratory of Bacteriology and Virology, Aristide Le Dantec University Hospital, Dakar, Senegal
Luc Kestens, Institute of Tropical Medicine, Unit of Immunology, Department of Biomedical Sciences, Antwerp, Belgium
Tandakha N. Dieye, Laboratory of Bacteriology and Virology, Aristide Le Dantec University Hospital, Dakar, Senegal
Abstract
Background: Tuberculosis (TB) has been shown to accelerate the clinical course of HIV infection, but the mechanisms by which this occurs are not well understood. Regulatory T-cells (Tregs)are known to dampen hyperactivation of the immune cells, but it remains unclear whether hyperactivation of T-cells in HIV infection is associated with a decrease of Tregs and what the effect Mycobacterium tuberculosis (MTB) co-infection has on T-cell activation and Tregs.
Objectives: In this study, we aim to evaluate whether active TB is associated with the increased expression of T-cell activation markers and reduced number of Treg cells in HIV-1-infected patients.
Methods: This study was conducted on 69 subjects consisting of 20 HIV-infected patients,20 HIV and MTB co-infected patients, 19 MTB-infected patients and 10 uninfected control subjects negative for both MTB and HIV. The frequencies of T-cell activation markers (CD38 and HLA-DR) and Treg cells (CD4+CD25+CD127-) were measured by flow cytometry.
Results: Significantly higher expression of CD38 and HLA-DR on CD4+ and CD8+ T-cells was found in MTB and HIV co-infected patients compared with HIV-infected patients. However,no significant difference in the percentage of Treg cells was reported between HIV patients with TB and those without. The study also showed a negative correlation between regulatoryT-cells frequency and CD4+ T-cell counts.
Conclusion: These results suggest that TB enhances the expression of peripheral T-cell activation markers during HIV infection, whilst having no impact on the percentages of Tregcells.
Keywords
Metrics
Total abstract views: 11036Total article views: 14487
Crossref Citations
1. Urban Air Pollution Particulates Suppress Human T-Cell Responses to Mycobacterium Tuberculosis
Olufunmilola Ibironke, Claudia Carranza, Srijata Sarkar, Martha Torres, Hyejeong Theresa Choi, Joyce Nwoko, Kathleen Black, Raul Quintana-Belmares, Álvaro Osornio-Vargas, Pamela Ohman-Strickland, Stephan Schwander
International Journal of Environmental Research and Public Health vol: 16 issue: 21 first page: 4112 year: 2019
doi: 10.3390/ijerph16214112
2. Activation and proliferation profiles of M.tuberculosis specific dual functional CD4+T cells from smear negative pulmonary TB patients
Ahmed Esmael, Adane Mihret, Tamrat Abebe, Daniel Mussa, Sebsib Neway, Joel Ernst, Jyothi Rengarajan, Liya Wassie, Rawleigh Howe, Angelo A. Izzo
PLOS One vol: 20 issue: 9 first page: e0327243 year: 2025
doi: 10.1371/journal.pone.0327243
3. Cytokine gene polymorphisms among North Indians: Implications for genetic predisposition?
Paras Singh, Roopali Rajput, Narinder K. Mehra, Madhu Vajpayee, Rohit Sarin
Infection, Genetics and Evolution vol: 73 first page: 450 year: 2019
doi: 10.1016/j.meegid.2019.06.004
4. T Cell Responses during Human Immunodeficiency Virus/Mycobacterium tuberculosis Coinfection
José Alejandro Bohórquez, Chinnaswamy Jagannath, Huanbin Xu, Xiaolei Wang, Guohua Yi
Vaccines vol: 12 issue: 8 first page: 901 year: 2024
doi: 10.3390/vaccines12080901
5. Mycobacterium tuberculosisantigen-specific T-cell responses in smear-negative pulmonary tuberculosis patients
Ahmed Esmael, Tamrat Abebe, Adane Mihret, Daniel Mussa, Sebsib Neway, Joel Ernst, Jyothi Rengarajan, Liya Wassie, Rawleigh Howe
Clinical and Experimental Immunology vol: 209 issue: 1 first page: 99 year: 2022
doi: 10.1093/cei/uxac049
6. Concurrent loss of co-stimulatory molecules and functional cytokine secretion attributes leads to proliferative senescence of CD8+ T cells in HIV/TB co-infection
Alireza Saeidi, Yee K. Chong, Yean K. Yong, Hong Y. Tan, Muttiah Barathan, Jayakumar Rajarajeswaran, Negar S. Sabet, Shamala D. Sekaran, Sasheela Ponnampalavanar, Karlhans F. Che, Vijayakumar Velu, Adeeba Kamarulzaman, Marie Larsson, Esaki M. Shankar
Cellular Immunology vol: 297 issue: 1 first page: 19 year: 2015
doi: 10.1016/j.cellimm.2015.05.005