Brief Report

Potential role of Lu/BCAM in HIV-related atherosclerosis

Modisa S. Motswaledi, Ishmael Kasvosve, Oluwafemi O. Oguntibeju
African Journal of Laboratory Medicine | Vol 8, No 1 | a792 | DOI: https://doi.org/10.4102/ajlm.v8i1.792 | © 2019 Modisa S. Motswaledi, Ishmael Kasvosve, Oluwafemi O. Oguntibeju | This work is licensed under CC Attribution 4.0
Submitted: 16 February 2018 | Published: 30 September 2019

About the author(s)

Modisa S. Motswaledi, Department of Biomedical Sciences, Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, Cape Town, South Africa; and, Department of Medical Laboratory Sciences, Faculty of Health Sciences, University of Botswana, Gaborone, Botswana
Ishmael Kasvosve, Department of Medical Laboratory Sciences, Faculty of Health Sciences, University of Botswana, Gaborone, Botswana
Oluwafemi O. Oguntibeju, Department of Biomedical Sciences, Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, Cape Town, South Africa

Abstract

Atheromatous lesions are formed by macrophages and low-density lipoprotein cholesterol invading the vascular intima. Here we show that increasing cholesterol levels are associated with peripheral monocyte depletion and this imbalance is aggravated by carriage of Lu/BCAM leukocyte adhesion molecules. This is true only in HIV infection and probably explains the risk of atherosclerosis observed in HIV-positive patients.

Keywords

cholesterol; Non-high-density lipoprotein cholesterol; Lu/BCAM; Atherosclerosis

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