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Epstein-Barr virus, human papillomavirus and herpes simplex virus 2 co-presence severely dysregulates miRNA expression

Jude O. Okoye, Anthony A. Ngokere, Charles C. Onyenekwe, Olaposi Omotuyi, Deborah I. Dada
African Journal of Laboratory Medicine | Vol 10, No 1 | a975 | DOI: https://doi.org/10.4102/ajlm.v10i1.975 | © 2021 Jude O. Okoye, Anthony A. Ngokere, Charles C. Onyenekwe, Olaposi Omotuyi, Deborah I. Dada | This work is licensed under CC Attribution 4.0
Submitted: 20 January 2019 | Published: 16 March 2021

About the author(s)

Jude O. Okoye, Department of Medical Laboratory Science, School of Public and Allied Health, Babcock University, Ilishan-Remo, Ogun State, Nigeria; and, Department of Medical Laboratory Science, Faculty of Health Sciences and Technology, College of Medicine, Nnamdi Azikiwe University, Nnewi campus, Anambra, Nigeria
Anthony A. Ngokere, Department of Medical Laboratory Science, Faculty of Health Sciences and Technology, College of Medicine, Nnamdi Azikiwe University, Nnewi campus, Anambra, Nigeria
Charles C. Onyenekwe, Department of Medical Laboratory Science, Faculty of Health Sciences and Technology, College of Medicine, Nnamdi Azikiwe University, Nnewi campus, Anambra, Nigeria
Olaposi Omotuyi, Department of Biochemistry, Centre for Biotechnology, Adekunle Ajasin University, Akungba-Akoko, Ondo, Nigeria
Deborah I. Dada, Department of Medical Laboratory Science, School of Public and Allied Health, Babcock University, Ilishan-Remo, Ogun State, Nigeria


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Abstract

This cross-sectional study evaluated the expression of miR-let-7b, miR-21, miR-125b, miR-143, miR-145, miR-155, miR-182, miR-200c, p53 gene, Ki67, SCCA1 and CD4+ T-cell counts among 319 women, to Epstein-Barr virus, human papillomavirus and herpes simplex virus 2 mono-infections and co-infections, using enzyme-linked immunosorbent assay and reverse transcriptase-polymerase chain reaction methods. This study suggests that malignancies associated with viral co-infection could be diagnosed early by monitoring cluster of differentiation 4+ T-cell counts and serum expression of miR-145 and miR-182.

Keywords

Epstein-Barr virus; human papilloma virus; herpes simplex virus 2; epithelial-mesenchymal transition; microRNAs

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